{"id":5978,"date":"2023-08-19T07:37:13","date_gmt":"2023-08-19T01:37:13","guid":{"rendered":"https:\/\/www.isrt.ac.bd\/?post_type=tribe_events&#038;p=5978"},"modified":"2023-08-19T07:37:13","modified_gmt":"2023-08-19T01:37:13","slug":"applied-statistics-and-data-science-seminar-on-monday-august-21-2023","status":"publish","type":"tribe_events","link":"https:\/\/isrt.ac.bd\/event\/applied-statistics-and-data-science-seminar-on-monday-august-21-2023\/","title":{"rendered":"Applied Statistics and Data Science Seminar on Monday, August 21, 2023"},"content":{"rendered":"<p><span style=\"color: #993366;\"><strong>Title:<\/strong><\/span>\u00a0Hierarchical structural component models for pathway analysis of longitudinal categorical phenotypes<\/p>\n<p><span style=\"color: #993366;\"><strong>Presenter:\u00a0<\/strong><\/span><\/p>\n<p>Md. Kamruzzaman, PhD<\/p>\n<p>Associate Professor, Jagannath Deltin 7 Aviator গেম টাকা ইনকাম, Email: kzaman1@isrt.ac.bd<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #993366;\"><strong>Abstract:<\/strong><\/span><\/p>\n<p>Several statistical methods for pathway analysis have been developed to test the association between pathways and phenotypes of interest. Since pathways are highly correlated, a hierarchical structural component models (HisCoM) was developed to analyze all pathways in a single model and take into consideration their correlation. HisCoM was originally developed to analyze a single phenotype using only one measurement per individual. Later, it was extended to analyze multiple phenotypes (HisCoM-multi) and longitudinal phenotypes (HisCoM-GEE). These methods have been used to analyze continuous, counts, and binary phenotypes from cross-sectional, clustered, and longitudinal studies. In this study, we propose a hierarchical structural component model for pathway analysis of longitudinal categorical phenotypes (HisCoM-RCateg). HisCoM-RCateg is proposed by combining the hierarchical structural component model and generalized estimating equations for correlated categorical phenotypes. HisCoM-RCateg accounts for the biological hierarchy of all biomarkers and pathways into a single model. In the simulation, the proposed HisCoM-RCateg appeared to have high power than other existing methods and effectively controlled type I error for longitudinal multinomial phenotypes. To demonstrate the performance, we also applied HiscoM-RCateg to two distinct types of longitudinal omics data, namely the metabolite dataset and the metagenome dataset.<\/p>\n<div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Title:\u00a0Hierarchical structural component models for pathway analysis of longitudinal categorical phenotypes Presenter:\u00a0 Md. Kamruzzaman, PhD Associate Professor, Jagannath Deltin 7 Aviator গেম টাকা ইনকাম, Email: kzaman1@isrt.ac.bd &nbsp; Abstract: Several statistical methods for pathway analysis have &#8230; <a class=\"\" href=\"https:\/\/isrt.ac.bd\/event\/applied-statistics-and-data-science-seminar-on-monday-august-21-2023\/\">[ Read More ]<\/a><\/p>\n","protected":false},"author":5,"featured_media":0,"template":"","meta":{"_acf_changed":false,"nf_dc_page":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[15],"class_list":["post-5978","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-seminar","cat_seminar"],"acf":[],"_links":{"self":[{"href":"https:\/\/isrt.ac.bd\/wp-json\/wp\/v2\/tribe_events\/5978","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/isrt.ac.bd\/wp-json\/wp\/v2\/tribe_events"}],"about":[{"href":"https:\/\/isrt.ac.bd\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"https:\/\/isrt.ac.bd\/wp-json\/wp\/v2\/users\/5"}],"version-history":[{"count":1,"href":"https:\/\/isrt.ac.bd\/wp-json\/wp\/v2\/tribe_events\/5978\/revisions"}],"predecessor-version":[{"id":5979,"href":"https:\/\/isrt.ac.bd\/wp-json\/wp\/v2\/tribe_events\/5978\/revisions\/5979"}],"wp:attachment":[{"href":"https:\/\/isrt.ac.bd\/wp-json\/wp\/v2\/media?parent=5978"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/isrt.ac.bd\/wp-json\/wp\/v2\/tags?post=5978"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"https:\/\/isrt.ac.bd\/wp-json\/wp\/v2\/tribe_events_cat?post=5978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}