{"id":879,"date":"2017-08-07T19:12:56","date_gmt":"2017-08-07T19:12:56","guid":{"rendered":"https:\/\/dev.isrt.ac.bd\/?post_type=tribe_events&p=879"},"modified":"2017-08-07T19:12:56","modified_gmt":"2017-08-07T19:12:56","slug":"seminar-on-tuesday-may-24-2016","status":"publish","type":"tribe_events","link":"https:\/\/isrt.ac.bd\/event\/seminar-on-tuesday-may-24-2016\/","title":{"rendered":"Seminar on Tuesday, May 24, 2016"},"content":{"rendered":"
Comparison of adaptive designs for dose \u001cfinding in phase I clinical trials<\/h1>\n
<\/div>\n
\n
May 20, 2016 – 3:45pm<\/em><\/span><\/p>\n
\n\n
\n
Full Title:<\/strong><\/td>\n
Comparison of adaptive designs for dose \u001cfinding in phase I clinical trials<\/td>\n<\/tr>\n
\n
Speaker:<\/strong><\/td>\n
Dr. M. Iftakhar Alam<\/td>\n<\/tr>\n
\n
<\/td>\n
Institute of Statistical Research and Training, Deltin 7 Aviator গেম টাকা ইনকাম of Deltin 7 bangladesh, Deltin 7 bangladesh-1000, Bangladesh<\/td>\n<\/tr>\n
\n
Date\/Time:<\/strong><\/td>\n
Tuesday, May 24, 2016<\/span>,\u00a03:30 p.m.<\/td>\n<\/tr>\n
The Continual reassessment method is a model based procedure that has been in the literature to determine the maximum tolerated dose in phase I clinical trials. The maximum tolerated dose can also be found under the framework of D-optimum design. This paper investigates the two methods to explore any potential differences between them. Simulation studies for six plausible dose-response scenarios show that the D-optimum design can work well over the continual reassessment method in many cases. The D-optimum design has also been found to allocate doses from the extremes of design region to the patients in a trial.<\/p>\n
Keywords: Dose \u001cfinding studies; Phase I trial; Maximum tolerated dose; Continual re-assessment method; D-optimum design.<\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"