Deltin 7

Deltin 7

Deltin 7 Aviator গেম টাকা ইনকাম of Barishal

বরিশাল বিশ্ববিদ্যালয়

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Department Publications

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551 Md. Ohidur Zaman , COVID-19 anxiety and associated factors among university students in Bangladesh Death Studies ,23 Feb 2023 Attachment
552 Md. Ohidur Zaman , Community resilience to natural disasters: A systemic review of contemporary methods and theories Natural Hazards Research ,1 June 2023 Attachment
553 Abu Salem , “Islam and Militancy” (Written in Bengali) BINIRMAN (A Regular Publication of Deltin 7 bangladesh Deltin 7 Aviator গেম টাকা ইনকাম Research Society (DURS) ,(December Issue, 2019, Deltin 7 Aviator গেম টাকা ইনকাম of Deltin 7 bangladesh, Bangladesh, pp. 62-65)
554 Abu Salem , “A Conceptual Framework of Corporate Social Responsibility: A Win-Win Situation” JIBON DARSHON (A Research Journal of Philosophy, published by Department of Philosophy, Jagannath Deltin 7 Aviator গেম টাকা ইনকাম, Deltin 7 bangladesh, Bangladesh) ,(Volume-9, published September 2021, ISSN 2312-7848, PP.287-296)
555 Abu Salem , “Judging the morality of business practices: moral issues in business focusing on Kant’s categorical imperatives” ANWESAN (A Research Journal of Philosophy, published by Philosophical Association of the Department of Philosophy, Deltin 7 Aviator গেম টাকা ইনকাম of Rajshahi, Bangladesh). ,(Volume-XIX, December 2020, ISNN 1995-7947, PP.87-96).
556 Abu Salem , “The Role of Ethics and Morals in Our Daily Life: A Philosophical Insight and Moral Progress” ”. Jagannath Deltin 7 Aviator গেম টাকা ইনকাম Journal of Arts, Faculty of Arts, ,(Volume 10, No 01, January-June 2020, ISNN: 2519-5816, pp.199-205)
557 Abu Salem , “Karl Marx’s Revolution and the Consciousness Role of Technology in the Development of Socialism" MANABABIDDA GABESANAPATRA (Double Blind Peer Reviewed Research Journal of Humanities, Published annually by Faculty of Arts, Jatiya Kabi Kazi Nazrul Islam Deltin 7 Aviator গেম টাকা ইনকাম, Trishal, Mymensingh, Bangladesh) ,(Issue 5, Asharh 1428, July 2021, ISSN 2518-5853, pp. 461-477)
558 Abu Salem , “Environmental Aesthetics: A Philosophically Informed Understanding of Aesthetic Values and Moral Judgment” ANWESAN (A Research Journal of Philosophy, published by Philosophical Association of the Department of Philosophy, Deltin 7 Aviator গেম টাকা ইনকাম of Rajshahi, Bangladesh). ,(Volume-XXI, December 2022)
559

Cultivating entrepreneurial aspirations: a comprehensive examination of university support, family support, and digital entrepreneurial knowledge on students’ digital entrepreneurial intention, Springer, Tehran Deltin 7 Aviator গেম টাকা ইনকাম 

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560

Background

The concurrent Zika Virus (ZIKV) outbreaks in the United States and Northeast Brazil have evoked global surveillance. Zika infection has been correlated with severe clinical symptoms, such as microcephaly, Guillain-Barré syndrome, and other congenital brain abnormalities. Recent data suggest that ZIKV predominantly targets neural progenitor cells leading to neurological impairment. Despite the clinical evidence, detailed experimental mechanism of ZIKV neurotropic pathogenesis has not been fully understood yet. Here we hypothesized that ZIKV produces miRNAs, which target essential host genes involved in various cellular pathways facilitating their survival through immune evasion and progression of disease during brain development.

Methods

From genome sequence information using several bioinformatic tools, we predicted pri-miRNAs, pre-miRNAs, and finally the mature miRNAs produced by ZIKV. We also identified their target genes and performed functional enrichment analysis to identify the biological processes associated with these genes. Finally, we analyzed a publicly available RNA-seq data set to determine the altered expression level of the targeted genes.

Results

From ZIKV genome sequence, we identified and validated 47 putative novel miRNAs. Functional enrichment of the targeted genes demonstrates the involvement of various biological pathways regulating cellular signaling, neurological functions, cancer, and fetal development. The expression analysis of these genes showed that ZIKV-produced miRNAs downregulate the key genes involved in these pathways, which in turn may lead to impaired brain development.

Conclusions

Our finding proposes novel ZIKV miRNAs and their targets, which upon experimental validation could help developing new therapeutics to combat ZIKV infection and minimize ZIKV-mediated pathologies.

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